China (Mainland)
PF-06463922 Loratinib CAS NO.1454846-35-5
- FOB Price: USD: 200.00-200.00 /Gram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,
- Available Specifications:
99%(1-10)Gram
- Product Details
Keywords
- PF-06463922
- 99% PF-06463922
- Loratinib
Quick Details
- ProName: PF-06463922 Loratinib
- CasNo: 1454846-35-5
- Molecular Formula: C21H19FN6O2
- Appearance: white powder
- Application: Anaplastic lymphoma kinase (ALK) is a ...
- DeliveryTime: 5-7 working days
- PackAge: As customer request
- Port: Qingdao/Shanghai
- ProductionCapacity: 20 Metric Ton/Month
- Purity: 99%
- Storage: Dry, sealed and protected from light
- Transportation: By Sea/Air/DHL/TNT/UPS
- LimitNum: 1 Kilogram
- Moisture Content: 0.02%
- Impurity: 0.01%
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Details
PF-06463922
[Product Name]:PF-06463922
[Synonyms]:Loratinib (PF-06463922);Lauratinib
[CAS]:1454846-35-5
[MF]:C21H19FN6O2
[MW]:406.4129632
[EINECS]:813-704-5
[Assay]:99%
[Package]:as customer request
[Customer Request]: Available
[Usage]:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]
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